Co-Sponsored by The Microcirculatory Society
Please note: The program schedule reflects Eastern Time.
Find out more about the App & Poster Sessions here.
Download poster sessions – June 2, June 3.
Note: Recordings of all Forum presentations will be available to registrants through June 19th.
Young Investigator Abstract Awards will be given to 4 selected submissions. First place will be awarded $500, and three runner-ups will be awarded $250.
Conference Schedule
The program schedule reflects Eastern Time.
Day 1, 5/31
12:00 pm–1:00 pm, Keynote Lecture, Kari Alitalo, Lymphatic biology, Translated to Medicine
Session 1. Lymphedema
Session Chair: Stan Rockson, Stanford
1:00 – 1:30 pm, Invited Talk, Babak Mehrara, Pathophysiology of Lymphedema
1:30 – 1:45 pm, Invited Talk, Barbara Garmy-Susini, Inflammation Resolution in Lymphedema
1:45 – 2:00 pm, The Kinetics of Lymphatic Dysfunction and Leukocyte Expansion in the Draining Lymph Node During LTB4 Antagonism in a Mouse Model of Lymphedema, Matthew T. Cribb
2:00 – 2:15 pm, Regional Valve Dysfunction in Collecting Lymphatic Vessels from Diet-Induced Obese Mice, Jorge Castorena-Gonzalez
2:15 – 2:30 pm, Decreased lymphatic HIF-2a accentuates lymphatic remodeling in lymphedema, Xinguo Jiang
2:30 – 2:45 pm, Break
Session 2. Lymphatics in Cancer Metastasis and Progression
Session Chair: Mihaela Skobe
2:45 – 3:15 pm, Invited Talk, Michael Detmar, Multiple Roles of Lymphatics in Cancer Progression and Inflammation
3:15 – 3:30 pm, Invited Talk, Tim Padera, Impaired Lymphocyte Infiltration into Lymph Node Metastases
3:30 – 3:45 pm, Lymph-Borne Melanoma-Derived Proteins as Determinants of Lymph Node Metastasis, Haley du Bois
3:45 – 4:00 pm, Adoptive T Cell Therapy Induces Tumor Lymphatic Vessel Dismantling and Inhibits Metastasis, Laure Garnier
4:00 – 4:15 pm, Investigating the Mechanisms Responsible for Lymphatic Vessel-mediated Egress of Tumor-specific CD8+ T Cells from Melanomas, Maria M. Steele
Day 2 – 6/1
Session 3. Genetic and Epigenetic Regulation of Lymphatics
Session Chair: Sathish Srinivasan
6:00 – 6:30 pm, Invited Talk, Natasha Harvey, Dissecting the Transcriptional Control of Lymphatic Endothelial Cell Identity
6:30 – 6:45 pm, Peritoneal Macrophages Regulate Vascular Integrity and Erythrocyte Uptake by Lymphatics in the Embryonic Omentum, Matthew Menendez
6:45 – 7:00 pm, VEGFR3 Deletion Dysregulates Lymphatic Permeability and Valve Development, Melanie Jannaway
7:00 – 7:15 pm, LETR1 is a Lymphatic Endothelial-Specific lncRNA Governing Cell Proliferation and Migration Through KLF4 and SEMA3C, Luca Ducoli
7:15 – 7:30 pm, FAT4 Regulates Remodelling of the Actin Cytoskeleton and Adhesion to Extracellular Matrix in Lymphatic Endothelial Cells, Anna Oszmiana
7:30 – 7:45 pm, Break
Session 4. Organ Specific Lymphatic Development
Session Chair: Anne Eichmann
7:45 – 8:15 pm, Invited Talk, Guillermo Oliver, Lymphatic Endothelial Cells: From Fate Specification to Organ Growth and Repair
8:15 – 8:30 pm, Understanding Notch4 Signaling in Adult Dermal Lymphatics, Glicella Salazar-De Simone
8:30 – 8:45 pm, Lymphatic-Derived Paracrine Signals Regulate Cardiac Growth and Repair, Xiaolei Liu
8:45 – 9:00 pm, Regulation of Lymphangiogenesis by Epsins And Mir-22 in Development and Disease, Hong Chen
9:00 – 9:15 pm, Delineating the Role of Neural Crest – and Endothelial-Derived FOXC2 in Schlemm’s Canal Morphogenesis and the Development of Glaucoma, Pieter R. Norden
Off schedule bonus at the end of day 2: Airing of the play, “Let’s Talk Lymphedema,” introduced by Kathy Bates, featuring Steve Guttenberg.
Day 3 – 6/2
Session 5. Innovating Lymphatic Therapy, Sponsored
by the Microcirculatory Society
Session Chair: Ying Yang
6:00 – 6:20 pm, Invited Talk, Isaac Lee, 3D in Vitro Model to Reconstitute Lymphatic Drainage
6:20 – 6:40 pm, Invited Talk, Shailesh Agarwal, Insight Gained from Mechanisms of Surgical Lymphedema Treatment
6:45 – 7:00 pm, Dantrolene Prevents Doxorubicin-Induced Lymphostasis and Preserves Lymph Flow in Vivo, Amanda J. Stolarz
7:00 – 7:15 pm, Lymphatic Mechanosensitivity To Intermittent Pneumatic Compression Is Altered by a Unilateral Collecting Lymphatic Injury, Anish Mukherjee
7:15 – 7:30 pm, FOXC2 Antagonizes DLL4 Expression to Regulate Lymphatic Vascular Patterning, Xin Geng
7:30 – 7:45 pm, Break
Session 6. Computational Modeling of Lymphatics
Session Chair: Lance Munn
7:45 – 8:15 pm, Invited Talk, Chris Bertram, Computational Modeling of Lymphatic Vessels
8:15 – 8:30 pm, Role of Valve Distribution on Pumping Performance of Collecting Lymphatics, Ki Wolf
8:30 – 8:45 pm, A Poroelastic Model of Interstitial Fluid Transport in the Limb with Gravity Effects, James Baish
8:45 – 9:00 pm, In-silico antigen transport model offers insights into the immunological role of the lymph node conduit system, Daniel J. Watson
9:00 – 9:15 pm, Modelling Lymph Uptake from the Interstitium into the Lymphatic System in the True Morphology of a Murine Dermal Network of Terminal Lymphatics, Ghazal Adeli Koudehi
POSTER SESSION IMMEDIATELY FOLLOWING
Download a list of today’s posters
Day 4 – 6/3
Session 7. Primary Lymphatic Diseases and Anomalies
Session Chair: Carrie Shawber
12:00 – 12:30 pm, Invited Talk, Pia Ostergaard, Genetics of Primary Lymphatic Anomalies
12:30 – 12:45 pm, Exome Sequencing in Complex Lymphatic Anomaly and Lymphedema Patients Supports Clinical Development for RASopathies, Dong Li
12:45 – 1:00 pm, Drugs that Target the PI3K Pathway Differentially Affect Venous and Lymphatic Malformation Endothelial Cells Carrying Pathogenic Pik3ca Variants, Noa Shapiro-Franklin
1:00 – 1:15 pm, Defective Lymphatic Valve Function in Mice with Deficiencies in Lymphatic Endothelial Cell Connexins 43, 47, 37 and/or 45, Michael J. Davis
1:15 – 1:30 pm, MDFIC Mutations Cause Autosomal Recessive Central Conducting Lymphatic Anomaly (CCLA), Drew Sutton
1:30 – 1:45 pm, Break
Session 8 – Lymphatic Connections with the Brain
Session Chair: Steven Proulx
1:45 – 2:15 pm, Invited Talk, Jonathan Kipnis, Meningeal Lymphatics Regulate Microglia Responses in Alzheimer’s Disease
2:15 – 2:30 pm, Altered Cerebrospinal Fluid Hydrodynamics Affect the Development of Meningeal Lymphatic Networks and the Glymphatic System in Craniosynostosis, Max Tischfield
2:30 – 2:45 pm, Tolerogenic Functions of Lymphatic Endothelial Cells in EAE, Camille Kowalski
2:45 – 3:00 pm, Magnetic Resonance Imaging of Cerebrospinal Fluid Outflow After Low-Rate Infusion into the Lateral Ventricle of Mice, Yann Decker
3:00 – 3:15 pm, Lymphangiogenesis Near the Cribriform Plate after Cerebral Ischemia, Yuna Choi
POSTER SESSION IMMEDIATELY FOLLOWING
Download a list of today’s posters
Day 5 – 6/4
Session 9. Lymphatic Drug Delivery
Session Chair: Susan Thomas
6:00 – 6:30 pm, Invited Talk, Natalie Trevaskis, Drug Delivery to Treat Lymphatic Related Diseases
6:30 – 6:45 pm, A Kidney-Targeted Nanoparticle to Augment Renal Lymphatic Density Decreases Blood Pressure in Mice with LNAME- and Angiotensin II-Induced Hypertension, Bethany Goodlett
6:45 – 7:00 pm, Engineering Nanoparticle Surface Chemistry to Maximize Lymph Node Delivery via Lymphatic Vessels, Jacob McCright
7:00 – 7:15 pm, Direct Access to Joint-Draining Lymphatics After Intra-articular Injection of Biologic Disease-Modifying Anti-Rheumatic Drugs, Alina Lam
7:15 – 7:30 pm, Lymphatic-Draining Nanoparticles Deliver Bay K8644 Payload to Lymphatic Vessels and Enhance Their Pumping Function, Lauren F. Sestito
7:30 – 7:45 pm, Break
Session 10. Lymphatics in the Gastrointestinal Tract and Lipid Metabolism
Session Chair: Mari Muthuchamy
7:45 – 8:15 pm, Invited Talk, Gou Young Koh, Regulation of Stromal and Immune Cells for Lacteal Integrity
8:15 – 8:30 pm, Invited Talk, Veronique Angeli, What Have We Learned from the Study of Cholesterol- Lymphatic Vessels Crosstalk?
8:30 – 8:45 pm, Acute Pancreatitis Causes Mesenteric Lymphatic Contractile Dysfunction Independent of Fluid Volume in a Rodent Model, Peter Russell
8:45 – 9:00 pm, Mesenteric Tertiary Lymphoid Organs Arising from Collecting Lymphatic Vessels Disrupts Gut to Lymph Node Communication and Immunity in IBD, Rafael Czepielewski
9:00 – 9:15 pm, Visceral Obesity and Insulin Resistance Associated with CD36 Deletion in Lymphatic Endothelial Cells, Vincenza Cifarelli
Day 6 – 6/5
Session 11. Lymphatics in Immunity and Inflammation
Session Chair: Gwen Randolph
12:00 – 12:30 pm, Invited Talk, Melody Swartz, Yin and Yang of Lymphatics in Pulmonary Inflammatory Diseases
12:30 – 12:45 pm, Invited Talk, Cornelia Halin, Mechanosensitive ACKR4 Scavenges CCR7 Chemokines to Facilitate T Cell De-Adhesion and Passive Transport by Flow in Afferent Lymphatics
12:45 – 1:00 pm, Joint-Draining Popliteal Lymphatic Vessels Exhibit Lymphatic Muscle Cell Dysfunction in TNF-Tg Mice with Inflammatory Arthritis, Mark H. Kenney
1:00 – 1:15 pm, Targeting Lymphatic Endothelial Cell IKKa Drives Formation of Bronchus Associated Lymphoid Tissue, Michelle Cully
1:15 – 1:30 pm, Popliteal Lymphatic Vessel Hyperactivity in the TNFdARE Spontaneous Arthritis Mouse Model, Flavia Neto de Jesus
1:30 – 1:45 pm, Break
Session 12. Organ Specific Lymphatic Physiology
Session Chair: Joe Rutkowski
1:45 – 2:15 pm, Invited Talk, Mark Nicolls, Airway Lymphatics in Transplantation
2:15 – 2:30 pm, Invited Talk, Ebba Brakenhielm, Regulation and Impact of Cardiac Lymphangiogenesis During Cardiac Hypertrophy
2:30 – 2:45 pm, Cigarette Smoke Causes Lung Lymphatic Dysfunction and Thrombosis in a Mouse Model of Emphysema, Hasina Outtz Reed
2:45 – 3:00 pm, Dichotomous Effects on Lymphatic Transport with Loss of Caveolae in Mice, Gaurav Baranwal
3:00 – 3:15 pm, Macroautophagy in Lymphatic Endothelial Cells Inhibits T-cell Mediated Autoimmunity, Stephanie Hugues
Off schedule bonus at the end of day 6: Airing of the play, “Let’s Talk Lymphedema,” introduced by Kathy Bates, featuring Steve Guttenberg.
